Our pharmacist answers the recent question concerning whether or no your deserve to take Benadryl (diphenhydramine) with Nyquil.

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At a glance

NyQuil includes doxylamine, a sedating first-generation antihistamine. Benadryl includes diphenhydramine, likewise a sedating first-generation antihistamine. Usage of both together increases the risk of side results such together oversedation, dry mouth, dry eyes and constipation.



In many cases, that is not encourage to take Benadryl (diphenhydramine) and also Nyquil together due to the fact that they both save on computer sedating antihistamines.<1>

The sedating antihistamine in NyQuil is doxylamine, which is an extremely closely pertained to diphenhydramine (the energetic ingredient in Benadryl). In fact, they space in the same course of medication, sedating first-generation antihistamines.

Taking 2 first-generation antihistamines together is taken into consideration "duplicate therapy" and also increases the danger of side impacts occurring.

What Is Benadryl?

Benadryl is classified as a an initial generation antihistamine. The duration of action of the medicine is commonly 4-6 hrs per sheep (25 mg come 50 mg).<2>

First generation antihistamines are well-known for their sedative effects and CNS (central concerned system) depressant effects. Plenty of individuals cannot tolerate the sedative impacts of Benadryl (diphenhydramine) during the work and, therefore, only take it in ~ bedtime come combat insomnia.

What Is NyQuil?

Nyquil is a combination cold/cough product that consists of the medicine doxylamine, together with a pain/fever reducer (acetaminophen) and a sneeze suppressant (dextromethorphan).

Doxylamine is a sedating first-generation antihistamine and also is in the same class of medication together Benadryl (diphenhydramine).<3>

Interaction Explained

As declared above, both doxylamine and Benadryl (diphenhydramine) work-related the same way and space actually in the same course of medication.

They work-related by prevent the histamine-1 receptor in the body, which stays clear of histamine from binding come it and also producing the symptom we are all very familiar v (e.g. Runny nose, watery eyes, etc...).

Since both drugs occupational the same way, utilizing both in ~ the exact same time is not recommended.

Combined use typically won"t provide any an ext benefit 보다 taking either alone. Additionally, acquisition them with each other not only rises the danger of excessive sedation, it considerably increases the threat of additional adverse results such as:<4>

Dry mouthDry eyesConstipationConstricted airways

Very high sheep of sedating antihistamines have additionally been linked with excitation, agitation, and also restlessness.<5>

When Is Use together Okay?

Having claimed that, there could be a instance to take the combination together.

Benadryl (diphenhydramine) has reasonably strong proof for use in stemming allergy reactions.

Studies display that Benadryl (diphenhydramine) can successfully reduce itching and also swelling from reactions to things favor bee stings and also poison ivy.

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If you have currently taken a dose of Nyquil and are having actually an allergic reaction to something, taking a dose of Benadryl (diphenhydramine) may help without a substantial increased hazard in intolerable next effects.