Medically reviewed by Alan Carter, Pinjury.D. — Written by Jill Seladi-Schulman, Ph.D. on December 19, 2018

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Acetaminophen (Tylenol) and ibuprofen (Advil) are both over-the-counter (OTC) drugs that deserve to be supplied to relieve pain.

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These medicines are 2 different forms of pain relievers. Acetaminophen, periodically listed as APAP, is its own kind, while ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID).

Normally, it’s safe to take acetaminophen and also ibuprofen together, however you’ll want to pay close attention to just how much you take of each medication.

The essential to safely taking acetaminophen and also ibuprofen is knowing how much you’re taking at a time and exactly how frequently.

Acetaminophen dosage

The maximum safe dosage of acetaminophen for anyone over the age of 12 is 4,000 milligrams (mg) per day. But also this amount have the right to harm some people’s livers, so aim for no more than 3,000 mg per day.

For children under the age of 12, it’s finest to examine via their healthcare provider to recognize the safest dose for their body weight.

Keep in mind that many kind of OTC medicines contain acetaminophen in a range of doses, typically 325 mg, 500 mg, or 650 mg.

Some examples of brand-name OTC drugs that may contain acetaminophen include:


Remember: When looking at labels, you could additionally see acetaminophen detailed as APAP.

Ibuprofen dosage

Avoid taking more that 1,200 mg of ibuprofen in a solitary day. OTC ibuprofen is frequently uncovered in 200 mg pills. This equates to six pills a day. Still, you should always verify how much is in each pill.

Aget, for youngsters, it’s best to ask their healthcare provider about the safest dose for their weight.

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If you have prescription-stamina ibuprofen, talk to your prescriber prior to mixing it via any kind of various other drugs, including acetaminophen.


The recommended boundaries for adults and kids over 12 are:

3,000 mg per day of acetaminophen1,200 mg per day of ibuprofen

For children under the age of 12, call their healthcare provider or describe the product label for dosage guidelines.

You deserve to take ibuprofen and acetaminophen at the same time. Just make sure to not take even more than the recommfinished dose.

Some human being suffer some stomach or abdominal pain once taking the 2 drugs together. In this case, it’s much better to alternative once you take each medication.

For instance, you could take ibuprofen first, adhered to by acetaminophen 4 hrs later on, and also then repeat this process as essential.

You might additionally alternate days. For instance, if you take ibuprofen on Monday, take acetaminophen on Tuesday and also so on.