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Fioricet is a prescription drug frequently used to treat tension headaches that contains the following active ingredients:

Acetaminophen 300 mgButalbital 50 mgCaffeine 40 mg

Each that these 3 ingredients remains in the human body for various lengths that time, definition that Fioricet have the right to stay in the device for as much as eight days.

You are watching: How long does butalbital stay in your system

Duration of impacts of Fioricet

The effects of Fioricet last for about 2–4 hours. The is typically prescribed as one or two capsules bring away by mouth every 4 hours.

Fioricet Half-Life

The half-life that a drug describes the time the takes for fifty percent of the dose to be got rid of from the bloodstream. Each ingredient in Fioricet has a unique half-life:

Acetaminophen: 2 hoursButalbital: 36 hoursCaffeine: 6 hours

The human body takes about five half-lives to eliminate a drug fully. Acetaminophen pipeline the body in 10 hours and also caffeine in 30 hours.

Butalbital has actually the longest half-life of the ingredient in Fioricet, so the remove time that the medicine is dependency on butalbital. Butalbital take away 180 hours, or nearly eight days, to leave the body.

How long Will Fioricet show in a medicine Test?

Most traditional drug tests will look because that barbiturates, including the butalbital in Fioricet. Different types of medicine tests may present traces that Fioricet for varying lengths that time. 


Several factors affect the detection home window of Fioricet, yet most pee tests will certainly pick up butalbital usage 3–7 days from the last dose.


Butalbital has actually a very long half-life and is detectable in blood for roughly 8 days. However, blood tests are not frequently used come detect medicine use since they space expensive and invasive.


Butalbital, among the main energetic ingredients in Fioricet, is detectable in saliva because that 2–3 days.


All drugs have actually a similar window the detection in hair tests. Throughout use, butalbital deposits into hair follicles and also becomes locked in the hair. Many tests take it 1.5 centimeters (cm) that hair because Fioricet deserve to be detect in hair because that 90 days.

Factors Affecting exactly how Long Fioricet stays in her System

There are several components that influence how long Fioricet continues to be in her system, including:

Amount usedFrequency the useAgeOverall health

The detection window for Fioricet is most affected by just how much of the medicine someone uses and how often. Butalbital take away a lengthy time to metabolize, for this reason it will certainly accumulate after just a couple of doses and also remain detectable in the human body for sometimes over a week.

False Positives because that Fioricet

Non-steroidal anti-inflammatory medicine (NSAIDs) favor ibuprofen and naproxen can cause false positives because that butalbital, yet this happens less than 1% that the time. 

A confident drug test will normally be sent out to an additional lab because that a check test referred to as gas chromatography-mass spectrometry (GC-MS). GC-MS test are very sensitive and specific, for this reason they will certainly not generally report false-positives.

How Fioricet Is damaged Down in the Body

Butalbital is greatly filtered the end of the blood through the kidneys and also removed in the urine. Acetaminophen and also caffeine space both metabolized and removed through the liver.

How to obtain Fioricet out of her System

The only means to remove drugs native the human body is to wait the ideal amount of time. Metabolizing organs, choose the kidney for butalbital, need time to remove drugs.

Key Points: How lengthy Does Fioricet remain in your System?

Fioricet consists of the three drugs acetaminophen, butalbital and caffeineButalbital can be detect in medicine screening testsButalbital takes countless days to leave the body, occasionally over a weekMost medicine tests have the right to detect butalbital for one mainly or longer

The only guaranteed way to pass a medicine test is by no taking the drug. If girlfriend or a love one struggle with an seeks to Fioricet, contact The Recovery town Ridgefield to learn more about treatment options.

Drost, Maureen L.; Walter, Leo. “Blood and Plasma concentrations of Butalbital Following single Oral sheep in Man.” newspaper of analytical Toxicology, November 1988. Accessed respectable 14, 2019.

Fritch, Dean; et al. “Barbiturate Detection in dental Fluid, Plasma, and Urine.” Therapeutic drug Monitoring, February 2011. Accessed July 30, 2019.

LabCorp. “Barbiturates, Screen and also Confirmation, Urine.” 2019. Accessed July 30, 2019.

Psychemedics. “Hair Drug testing Facts.” 2015. Accessed July 30, 2019.

U.S. Nationwide Library that Medicine. “Fioricet package Insert.” December 19, 2017. Accessed July 30, 2019.

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