Part 1

Which rat had actually the more quickly basal metabolic rate (BMR)?

The normal rat had the faster basal metabolic rate, since it to be not missing its pituitary gland or that is thyroid gland.

You are watching: Why did the tsh have no effect on the bmr of the thyroidectomized rat?

Why did the metabolic rates differ in between the normal rat and the surgically altered rats? just how well go the outcomes compare through your prediction? The regular rat has actually the greatest BMR because it has actually the glands forced to stimulate and also regulate the release of thyroid hormones.

If an animal has to be thyroidectomized, what hormone(s) would be absent in its blood? Triiodothyronine and thyroxine.


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If an pet has been hypophysectomized, what effect would you expect to watch in the hormone level in that is body? because that the hypophysectomized rat, TSH would be lacking due come the absent pituitary gland.

Part 2

What was the impact of thyroxine injections top top the common rat’s BMR? The levels were a little off. The typical rat was hyperthyroidic due to the fact that the thyroxine increases the metabolic rate but it go not develop a goiter.


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What to be the result of thyroxine injections ~ above the thyroidectomized rat’s BMR? just how does the BMR in this situation compare v the common rat’s BMR? to be the sheep of thyroxine in the syringe as well large, as well small, or simply right? The BMR boosted for the thyroidectomized rat v the thyroxine injections.


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The BMR was still a tiny bit under the typical rat’s BMR v thyroxine. The sheep was as well low.

What was the effect of thyroxine injections top top the hypophysectomized rat’s BMR? how does the BMR in this situation compare v the typical rat’s BMR? was the sheep of thyroxine in the syringe too large, also small, or just right? The BMR raised for the hypophysectomized rat v the thyroxine injections. The BMR was still a little bit under the regular rat’s BMR v thyroxine. The sheep was too low

Part 3

What was the impact of thyroid-stimulating hormone (TSH) injections ~ above the common rat’s BMR? The impact of TSH was to increase the typical rat’s BMR

What to be the result of TSH injections on the thyroidectomized rat’s BMR? just how does the BMR in this case compare v the regular rat’s BMR? Why to be this result observed? There was no impact on the thyroidectomized rat’s BMR with the injection of TSH because there was no thyroid gland come stimulate. What was the result of TSH injections ~ above the hypophysectomized rat’s BMR? how does the BMR in this instance compare through the normal rat’s BMR? to be the sheep of TSH in the syringe too large, too small, or just right? The hypophysectomized rat’s BMR enhanced with TSH. The BMR was just listed below the common rat’s BMR however still lower. The syringe amount was a tiny too low.

Part 4

What was the impact of propylthiouracil (PTU) injections ~ above the regular rat’s BMR? Why walk this rat construct a palpable goiter? The impact of PTU injections ~ above the typical rat was to decrease the BMR. The palpable goiter was due to buildup of the precursors the thyroxine. What was the effect of PTU injections top top the thyroidectomized rat’s BMR? how does the BMR in this case compare v the common rat’s BMR? Why was this effect observed? The result of PTU injections ~ above the thyroidectomized rat was not visible due to the fact that there was no thyroid gland to be affected. What to be the result of PTU injections ~ above the hypophysectomized rat’s BMR? just how does the BMR in this instance compare v the common rat’s BMR? Why to be this result observed? The impact of PTU injections ~ above the hypophysectomized rat was no visible because the rat is absent the pituitary gland. Activity 2 Plasma Glucose, Insulin, and Diabetes Mellitus

What is a glucose conventional curve, and also why go you require to obtain one because that this experiment? go you effectively predict exactly how you would certainly measure the amount of plasma glucose in a patience sample using the glucose typical curve? The glucose conventional curve correlates the soot of the color obtained and also measured ~ above a spectrophotometer (optical density) to the glucose concentration. Which patient(s) had actually glucose reading(s) in the diabetic range? have the right to you say through certainty whether each of this patients has form 1 or form 2 diabetes? Why or why not? patience 3 and also 5 had actually a fasting plasma glucose in the diabetic range. That is not possible to tell if they have form 1 or form 2 diabetes simply from their fasting plasma glucose. 3. Describe the diagnosis because that patient 3, who was also pregnant at the time of this assay. This would certainly be described as gestational diabetes which regularly disappears after ~ the pregnancy. Which patient(s) had normal glucose reading(s)?

Patient 1 and 2 were in typical range.

What room some lifestyle selections these patients through normal plasma glucose readings might recommend to the borderline impaired patients? limit the sloop down of simple sugars. Choose an excellent carbs such overall wheat and fiber based carbohydrate choices. Exercise regularly.

Activity 3 Hormone replacement Therapy

Why to be ovariectomized rats supplied in this experiment? just how does the reality that the rats space ovariectomized explain their baseline T scores? The ovaries produce estrogen and estrogen stimulates bone growth. Without estrogen bone development is impaired and osteoporosis is a common result. What impact did the management of saline injections have actually on the manage rat? how well go the results compare through your prediction? Saline had no effect. The consist of of the saline as a an adverse control is come ensure that saline has actually no effect. What effect did the administration of estrogen injections have on the estrogen-treated rat? just how well did the outcomes compare with your prediction? The estrogen injections did increase the rats vertebral bone density and is suggested by the an unfavorable T score.

What effect did the administration of calcitonin injections have actually on the calcitonin-treated rat? exactly how well walk the outcomes compare v your prediction? The calcitonin showed no change in the vertebral bone density. What room some health risks that postmenopausal women must think about when contemplating estrogen hormone replacement therapy? Health threats of estrogen therapy include an enhanced incidence the uterine cancer, breast cancer, and also blood clots. Task Measuring Cortisol and also Adrenocorticotropic Hormone 1 i beg your pardon patient would certainly most likely be diagnosed through Cushing’s disease? Why? Patient would certainly be diagnosed bc the level of cortisol and also ACTH space both high.

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Which 2 patients have actually hormone levels characteristic that Cushing’s syndrome? patients 2 and also 5 both have high level of cortisol and also low ACTH. 3 patience 2 is being treated because that rheumatoid arthritis v prednisone. How does this information change the diagnosis? The diagnosis would adjust to iatrogenic or medical professional induced Cushings syndrome. 4 i m sorry patient would certainly most most likely be diagnosed v Addison’s disease? Why? patient 4 bc the level of ACTH is high but the level of cortisol is low.